Therapeutic Benefits

An image of hexagonal molecules with herbs inside each hexagon and a microscope off to the left to indicate research of the herbs.


Synergy BioNaturals pipeline currently includes three condition-specific CBD formulations for stress, pain, and sleep. 


β-Calmed (Stress)


SBN’s stress-relief formula, which includes Broad-Spectrum CBD, promotes relaxation by supporting a healthy stress response. Research has shown that a disruption in the body’s response to physical and emotional stressors contributes to anxiety.  


β-Calmed works by aiding the body’s inhibitory actions on the stress response and supporting systemic balance. 


Anxiety involves large interneuronal networks that can be difficult to manage in a state of excitability. Reducing the generation and accessibility of large constellations of brain networks promotes calm and relaxation.  


Synergy BioNaturals β-Calmed Ingredients


CBD Broad Spectrum elevates the endogenous cannabinoid Anandamide which has been shown to increase connections between different areas of the brain such as the limbic system (seat of emotions & memory) and the prefrontal cortex (logic, planning) allowing better emotional processing of anxiety based memories.  


Shoden® Ashwagandha provides the bioactive polyphenolic compounds glycowithanolides, which can protect the brain from oxidative stress by increasing the activity of endogenous antioxidant enzymes. Shoden® Ashwagandha is a powerful adaptogen that can help the body adapt and recover from stress.


Suntheanine® has been shown to promote Alpha wave activity in higher brain regions. Suntheanine® promotes a healthy stress response in the Hypothalamic Pituitary Adrenal Axis (HPA) by supporting the anxiolytic effects of the neurotransmitter GABA.


Myrcene is a natural muscle relaxant that induces the “couch-lock” sedative effect. Myrcene synergizes with other terpenes to calm the body, which promotes calm. 


β-Caryophyllene combats chronic stress by crossing the blood-brain barrier and binding to the CB2 receptor activating the endocannabinoid system.  


β-Relieved (Pain) 


SBN’s pain relief formula, which includes Broad Spectrum CBD, works to address the underlying causes of chronic inflammation and pain. β-Relieved is a safe and effective alternative to NSAIDs and other over the counter medications. 


β-Relieved combines the wisdom of ancient healing systems with modern advances in biochemistry to activate the body’s anti-inflammatory pathways. The synergy of phytochemicals, cannabinoids, and terpenes work naturally within the body to support health & wellness. 


Inhibiting inflammation involves modulating the activity of pro-inflammatory enzymes such as 5-Lipoxygenase and TNF-a. The synergy between compounds has a greater biological effect than the action of isolated ingredients. 


The immune system uses proinflammatory and anti-inflammatory cytokines to coordinate its activities. An anti-inflammatory action can naturally modulate inflammatory pathways, changing how the immune system communicates with itself.  


Synergy BioNaturals β-Relieved Ingredients  


CBD Broad Spectrum (Cannabidiol) has been shown to activate TRPV1 Vanilloid receptors, which play an essential role in pain perception, body temperature, and inflammation. Activation of TRPV1 shifts how the brain processes noxious stimuli. 


CBC (Cannabichromene) is a lesser-known cannabinoid that modulates pain by inhibiting endocannabinoid degradation. 


CBG (Cannabigerol) has been shown to prevent oxidative induced inflammation by modulating cytoprotective antioxidant transcription factors such as nuclear factor erythroid 2-related factor 2 (Nrf2).   


Boswellia as 5-Lox® has shown in studies to inhibit the activity of 5-lipoxygenase and TNF-a, halting the inflammatory driven destruction of soft tissues.


Turmeric Extract as BCM95® has exhibited in research to inhibit chronic pain by shutting off the “master inflammatory switch” nuclear factor kappa-b (NF-kB), which activates over 150 genes involved in systemic inflammation.


Ginger 5mg Shogoals not only increases the bioavailability of Boswellia and Turmeric but ginger aids in the treatment of inflammatory driven conditions such as osteoarthritis and rheumatoid arthritis by inhibiting the biosynthesis of pro-inflammatory hormones.


a-pinene is a powerful anti-inflammatory that is able to inhibit many proinflammatory enzymes involved in systemic inflammation. A-pinene has shown an ability to block NF-kb “the master inflammatory switch,” which activates over 150 genes that encode proinflammatory proteins and enzymes.


Myrcene is a natural muscle relaxant that induces the “couch-lock” sedative effect when synergized with other terpenes such as Limonene. Myrcene has been shown to exert its anti-inflammatory benefits by inhibiting the activity of the eicosanoid PGE2.


d-Limonene synergizes with the terpene myrcene increasing its anti-inflammatory, anti-oxidative, and anti-proliferative benefits.


β-Caryophyllene combats chronic low-level inflammation by modulating adaptive immune cell lines. β-Caryophyllene is highly lipophilic, giving it the unique ability to cross the blood-brain barrier and bind to the CB2 receptor activating the endocannabinoid system. 


β-Rested (Sleep)


SBN’s sleep formula promotes the natural stages of sleep by first reducing the time it takes to fall asleep. The nutraceuticals in β-Rested such as Valerian Root and CBD, support the inhibitory actions of adenosine and GABA, which modulate neuronal pathways that promote wakefulness and prevent sleep. 


β-Rested allows the brain to get into slow-wave sleep (REM), which is essential for cellular maintenance, repair, and renewal. Anxiety often underlies sleep disorders disrupting neuronal excitation and inhibition. 


Blood sugar levels elevate during times of emotional distress to promote wakefulness. Insufficient sleep lowers stress thresholds, which increase anxiety, stimulating a sympathetic fight or flight stress response that promotes arousal. β-Rested promotes Alpha wave activity in higher brain regions reducing the time it takes to fall asleep while naturally initiating the natural cycles of sleep.



β-Rested Ingredients


CBD Broad Spectrum has been shown in studies to inhibit the uptake of the neuromodulator adenosine, which plays a fundamental role in suppressing arousal and inducing sleep.


Suntheanine® has been shown in studies to bind to glutamate receptors, inhibiting excitatory activity in the brain. Suntheanine® is noticeable within 30 mins of ingestion and exerts a calming effect by supporting the activity of GABA. 


Valerian (Valerenic Acid 2.4mg 0.8%) has been used since antiquity to treat sleep disorders, and modern research has validated its mechanism of action, which is the activation of the GABA receptors involved in inhibiting the firing of neurons.


5-Hydroxytryptophan (5-HTP) is extracted from the seed of an African plant known as Griffonia Simplicifolia. 5-HTP is taken up by the body and enzymatically converted in the brain to serotonin. Serotonin is used to create the sleep hormone melatonin, which influences sleep-wake cycles (circadian rhythms).


β-Caryophyllene is highly lipophilic, giving it the unique ability to cross the blood-brain barrier and bind to the CB2 receptor, where it provides anxiolytic benefits.


Linalool is a calming monoterpene found in Lavender that works through the GABAergic system to promote inhibition of neuronal activity.

B-Myrcene is a natural muscle relaxant that is known to promote the “couch-lock” sedative effect in some cannabis strains. Researchers studying the habits of insomniacs noted that sleep occurred when subjects underwent a bedtime ritual that included relaxing the body, which invariably promotes the inhibitory networks involved in onset sleep latency.





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